Connection between GABA and P5P

Pyridoxal-5'-phosphate (vitamin-B6) is an essential cofactor to GABA synthesis. An individual with a genetic pyridoxine metabolism abnormality or one who is taking a pyridoxine antagonist (i.e. isoniazid) may experience inadequate GAD activity and will have significant GABA deficiency leading to symptoms of irritability and confusion (Kaplan & Sadock, 1995). Confusion and irritability are symptoms often associated with schizophrenia (American Psychiatric Association, 1994).

Well, as you know, I take a whole bucket of this stuff a day. Its not that simple, as p5p also potentiates dopamine and norepinephrine. really, I should leave this stuff to the professionals.