Notes from the other side
This is a snippet from a correspondence with X, who recently found out that he is going to be treate, by the PTC, as a histadelic. Histadelia, for those of you new to this blog, is characterized by high histamine levels, over 70 in whole blood histamine tests, and low methylation. In short, the Mythyl folate ration is skewed toward methyl groups.
So that is what the web says, but the pointof this blog is letting you know what it feels like on the inside. X wrote to me and I thought I would share this with you histadelics out there because it gives some insight, and because it appears the guy aniled right on what was happening inside him. Amazing what brains and motivation can do:
"After gathering my thoughts for a few days...here is how I interpret my situation. I have been actively histadelic for years. All of the signs were there during my high school years (dating back ten years). With histadelia though, some of the 'symptoms' seem to almost work to our advantage. I mean the competitiveness, hard-driving, high libido life seems normal in a world that relishes those characteristics. I believe though that the body can only handle this amount of NT excessive output for so long until the histamine continues to rise and the symptomology of our disease becomes a burden. Whatever the case, I look forward to improving and, with any luck, resuming some sort of a life.
Adrenal burnout from histadelia could result as excessive adrenaline is pumped into the system to counteract the excessive levels of histamine. I think allergic reactions are brought on by histamine....so when a person is allergic to a bee sting...what actually results is an excessive histamine outpour. This is counteracted by an 'epipen' or whatever. An epipen is basically pure adrenaline, which counteracts the histamine. My body is constantly attempting to produce adrenaline to counteract histamine, perhaps this is where the internal anxiety is derived from. And you want to talk high internal anxiety, it can be completely gripping at time. It is hard to imagine a time in my future where I will once again experience a sense of peace...serenity. "
Well said.
Individuals with high-histamine levels may be due to a metabolic imbalance that
results from under-methylation.... For some individuals, high levels of blood
histamine (called histadelia) have psychological, behavioral, and cognitive
symptoms.
Many patients with obsessive-compulsive tendencies,
"oppositional-defiant disorder," or seasonal depression are under-methylated,
which is associated with low serotonin levels. Often with inhalant
allergies, frequent headaches, perfectionism, competitiveness and other
distinctive symptoms and traits. Tend to be very low in calcium, magnesium,
methionine, and vitamin B-6 with excessive levels of folic acid. People with
histadelics have a positive effect from SSRIs and other serotonin-enhancing
medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation
is a step in the manufacture of mood stabilizing neurotransmitters.
Unfortunately, histadelics often have nasty side effects with these medications.
Histamine excess can be manifest as asthma, vasomotor rhinitis,
allergic skin disorders with pruritis, excess stomach acid production (acts as a
gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and
bronchial secretions, and certain types of vascular headaches. This is the
basis of anti-histamine medications. Excessive histamine results because of the
inadequate methylation in liver detoxification. Histamine opposes
adrenalin in its effects and as expected fatigue occurs just as it occurs in
adrenal exhaustion.
Biochemical treatment revolves around
antifolates, especially calcium and methionine. Certain forms of buffered
vitamin C can help by providing calcium and ascorbic acid. Three to six
months of nutrient therapy are usually needed to correct this chemical
imbalance. As in most biochemical therapies, the symptoms usually return if
treatment is stopped.
Methylation is involved in DNA synthesis,
masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve
myelination, carnitine and coenzyme Q 10 synthesis. The relationship of
mood and behavior to Histadelia is due to the fact that methylation is involved
in neurotransmitter synthesis.http://www.drkaslow.com/html/histadelia.html
So that is what the web says, but the pointof this blog is letting you know what it feels like on the inside. X wrote to me and I thought I would share this with you histadelics out there because it gives some insight, and because it appears the guy aniled right on what was happening inside him. Amazing what brains and motivation can do:
"After gathering my thoughts for a few days...here is how I interpret my situation. I have been actively histadelic for years. All of the signs were there during my high school years (dating back ten years). With histadelia though, some of the 'symptoms' seem to almost work to our advantage. I mean the competitiveness, hard-driving, high libido life seems normal in a world that relishes those characteristics. I believe though that the body can only handle this amount of NT excessive output for so long until the histamine continues to rise and the symptomology of our disease becomes a burden. Whatever the case, I look forward to improving and, with any luck, resuming some sort of a life.
Adrenal burnout from histadelia could result as excessive adrenaline is pumped into the system to counteract the excessive levels of histamine. I think allergic reactions are brought on by histamine....so when a person is allergic to a bee sting...what actually results is an excessive histamine outpour. This is counteracted by an 'epipen' or whatever. An epipen is basically pure adrenaline, which counteracts the histamine. My body is constantly attempting to produce adrenaline to counteract histamine, perhaps this is where the internal anxiety is derived from. And you want to talk high internal anxiety, it can be completely gripping at time. It is hard to imagine a time in my future where I will once again experience a sense of peace...serenity. "
Well said.
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